Arsenal will be targeting a return to winning ways when they welcome English Premier League strugglers Southampton to the Emirates Stadium on December 11.
 

West Ham United will host 2021/22 English Premier League pacesetters Chelsea in a London derby on Saturday afternoon. 

Watford FC will battle with Chelsea FC in an English Premier League match at Vicarage Road on December 1.
 

Watford will be eager to build on a morale-boosting 2021/22 English Premier League win when they take aim at Leicester City at King Power Stadium on Sunday. 
 

West Ham United will be aiming to build on their impressive run of form in the 2021/22 English Premier League season when they take aim at Wolverhampton Wanderers this Saturday. 
 

Both Crystal Palace and Wolverhampton Wanderers will put their respective unbeaten runs in the 2021/22 English Premier League season on the line, when they meet at Selhurst Park on Saturday. 

Defending champions Manchester City will be aiming to build on their unbeaten run in the 2021/22 English Premier League season with victory over Crystal Palace at Etihad Stadium on Saturday. 

Former Chelsea and Leicester City manager, Claudio Ranieri, will be eyeing the perfect start to his reign as Watford boss when they host Liverpool in a 2021/22 English Premier League match at Vicarage Road on Saturday.

Arsenal FC will renew their heated rivalry with their London neighbours Tottenham Hotspur in a Premier League match at the Emirates Stadium on September 26.

Manchester United will be eager to build on a confident start to the 2021/22 English Premier League season when they take on West Ham United in London on Sunday afternoon